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Angel Pellicer - Premios Atlántico de Investigación del Cáncer

2002 – I Conferencia Atlántica del Cáncer

Tarragona, 1946

Catedrático de Bioquímica
Universidad de Nueva York

Publicaciones Recientes:

1. Perez de Castro I, Bivona TG, Philips MR, Pellicer A.
Ras activation in Jurkat T cells following low-grade stimulation of the T-cell receptor is specific to N-Ras and occurs only on the Golgi apparatus.
Mol Cell Biol. 2004 Apr;24(8):3485-96.

2. Gao J, Huang HY, Pak J, Cheng J, Zhang ZT, Shapiro E, Pellicer A, Sun TT, Wu XR.
p53 deficiency provokes urothelial proliferation and synergizes with activated Ha-ras in promoting urothelial tumorigenesis.
Oncogene. 2004 Jan 22;23(3):687-96.

3. Tseng JC, Levin B, Hurtado A, Yee H, Perez de Castro I, Jimenez M, Shamamian P, Jin R, Novick RP, Pellicer A, Meruelo D.
Systemic tumor targeting and killing by Sindbis viral vectors.
Nat Biotechnol. 2004 Jan;22(1):70-7.

4. Diaz R, Lopez-Barcons L, Ahn D, Garcia-Espana A, Yoon A, Matthews J, Mangues R, Perez-Soler R, Pellicer A.
Complex effects of Ras proto-oncogenes in tumorigenesis.
Carcinogenesis. 2004 Apr;25(4):535-9. Epub 2003 Nov 21.

5. Corral T, Jimenez M, Hernandez-Munoz I, Perez de Castro I, Pellicer A. NF1 modulates the effects of Ras oncogenes: evidence of other NF1 function besides its GAP activity.
J Cell Physiol. 2003 Nov;197(2):214-24.

6. Hernandez-Munoz I, Benet M, Calero M, Jimenez M, Diaz R, Pellicer A. rgr oncogene: activation by elimination of translational controls and mislocalization.
Cancer Res. 2003 Jul 15;63(14):4188-95.

7. Bivona TG, Perez De Castro I, Ahearn IM, Grana TM, Chiu VK, Lockyer PJ, Cullen PJ, Pellicer A, Cox AD, Philips MR.
Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1.
Nature. 2003 Aug 7;424(6949):694-8.

8. de Castro IP, Diaz R, Malumbres M, Hernandez MI, Jagirdar J, Jimenez M, Ahn D, Pellicer A.
Mice deficient for N-ras: impaired antiviral immune response and T-cell function.
Cancer Res. 2003 Apr 1;63(7):1615-22.

9. Matallanas D, Arozarena I, Berciano MT, Aaronson DS, Pellicer A, Lafarga M, Crespo P.
Differences on the inhibitory specificities of H-Ras, K-Ras, and N-Ras (N17) dominant negative mutants are related to their membrane microlocalization.
J Biol Chem. 2003 Feb 14;278(7):4572-81.

10. Diaz R, Ahn D, Lopez-Barcons L, Malumbres M, Perez de Castro I, Lue J, Ferrer-Miralles N, Mangues R, Tsong J, Garcia R, Perez-Soler R, Pellicer A.
The N-ras proto-oncogene can suppress the malignant phenotype in the presence or absence of its oncogene.
Cancer Res. 2002 Aug 1;62(15):4514-8.

11. Leonardi P, Kassin E, Hernandez-Munoz I, Diaz R, Inghirami G, Pellicer A.
Human rgr: transforming activity and alteration in T-cell malignancies.
Oncogene. 2002 Aug 1;21(33):5108-16.

12. Cheng J, Huang H, Zhang ZT, Shapiro E, Pellicer A, Sun TT, Wu XR.
Overexpression of epidermal growth factor receptor in urothelium elicits urothelial hyperplasia and promotes bladder tumor growth.
Cancer Res. 2002 Jul 15;62(14):4157-63.

13. Zhang ZT, Pak J, Huang HY, Shapiro E, Sun TT, Pellicer A, Wu XR.
Role of Ha-ras activation in superficial papillary pathway of urothelial tumor formation.
Oncogene. 2001 Apr 12;20(16):1973-80.

14. Hernandez-Munoz I, Malumbres M, Leonardi P, Pellicer A.
The Rgr oncogene (homologous to RalGDS) induces transformation and gene expression by activating Ras, Ral and Rho mediated pathways.
Oncogene. 2000 May 25;19(23):2745-57.

15. Melendez B, Malumbres M, de Castro IP, Santos J, Pellicer A, Fernandez-Piqueras J.
Characterization of the murine p19(ARF) promoter CpG island and its methylation pattern in primary lymphomas.
Carcinogenesis. 2000 Apr;21(4):817-21.

16. Malumbres M, Perez De Castro I, Hernandez MI, Jimenez M, Corral T, Pellicer A.
Cellular response to oncogenic ras involves induction of the Cdk4 and Cdk6 inhibitor p15(INK4b).
Mol Cell Biol. 2000 Apr;20(8):2915-25.

17. Garcia-Espana A, Biria S, Malumbres M, Levin B, Meruelo D, Pellicer A.
Targeted gene transfer system using a streptavidin-transforming growth factor-alpha chimeric protein.
DNA Cell Biol. 1999 Oct;18(10):743-9.

18. Perez de Castro IP, Malumbres M, Santos J, Pellicer A, Fernandez-Piqueras J. Cooperative alterations of Rb pathway regulators in mouse primary T cell lymphomas.
Carcinogenesis. 1999 Sep;20(9):1675-82.

19. Malumbres M, Perez de Castro I, Santos J, Fernandez Piqueras J, Pellicer A. Hypermethylation of the cell cycle inhibitor p15INK4b 3'-untranslated region interferes with its transcriptional regulation in primary lymphomas.
Oncogene. 1999 Jan 14;18(2):385-96.

20. Mangues R, Corral T, Lu S, Symmans WF, Liu L, Pellicer A.
NF1 inactivation cooperates with N-ras in in vivo lymphogenesis activating Erk by a mechanism independent of its Ras-GTPase accelerating activity.
Oncogene. 1998 Oct 1;17(13):1705-16.

21. Corominas M, Kamino H, Leon J, Pellicer A.
Oncogene activation in human benign tumors of the skin (keratoacanthomas): is HRAS involved in differentiation as well as proliferation?
Proc Natl Acad Sci U S A. 1989 Aug;86(16):6372-6.

22. Guerrero I, Villasante A, Corces V, Pellicer A.
Loss of the normal N-ras allele in a mouse thymic lymphoma induced by a chemical carcinogen.
Proc Natl Acad Sci U S A. 1985 Dec;82(23):7810-4.

23. Guerrero I, Villasante A, Corces V, Pellicer A.
Activation of a c-K-ras oncogene by somatic mutation in mouse lymphomas induced by gamma radiation.
Science. 1984 Sep 14;225(4667):1159-62.

24. Guerrero I, Villasante A, D'Eustachio P, Pellicer A.
Isolation, characterization, and chromosome assignment of mouse N-ras gene from carcinogen-induced thymic lymphoma.
Science. 1984 Sep 7;225(4666):1041-3.

25. Guerrero I, Calzada P, Mayer A, Pellicer A.
A molecular approach to leukemogenesis: mouse lymphomas contain an activated c-ras oncogene.
Proc Natl Acad Sci U S A. 1984 Jan;81(1):202-5.

26. Pellicer A, Robins D, Wold B, Sweet R, Jackson J, Lowy I, Roberts JM, Sim GK, Silverstein S, Axel R.
Altering genotype and phenotype by DNA-mediated gene transfer.
Science. 1980 Sep 19;209(4463):1414-22.

27. Pellicer A, Wigler M, Axel R, Silverstein S. Related Articles, Links
The transfer and stable integration of the HSV thymidine kinase gene into mouse cells.
Cell. 1978 May;14(1):133-41.

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